Efficacy of granulocyte colony-stimulating factor for infertility undergoing IVF: a systematic review and meta-analysis

Efficacy of granulocyte colony-stimulating factor for infertility undergoing IVF: a systematic review and meta-analysis

Blog Article

Abstract Objective This study aimed to evaluate the effectiveness of granulocyte colony-stimulating factor (G-CSF) for infertility and recurrent spontaneous abortion.Methods Existing research was searched in PubMed, Embase and Cochrane Library till Dec 2021.Randomized control trials (RCTs) that compared G-CSF administration with the control group in infertility women undergoing IVF were included.The primary outcomes included clinical pregnancy rate; the secondary outcomes included live birth rate, abortion ratebiochemical pregnancy rate, embryo implantation rate, as well as iphone 14 pro max las vegas endometrial thickness.

Result(s) 20 RCTs were included in this study.G-CSF increased the clinical pregnancy rate (RR = 1.85; 95% CI: 1.07, 3.

18) and the endometrial thickness (MD = 2.25; 95% CI: 1.58,2.92;) in patients with thin les benjamins ta?l? sweatshirt endometrium undergoing IVF.

G-CSF increased the biochemical pregnancy rate (RR = 2.12; 95% CI: 1.54, 2.93), the embryo implantation rate (RR = 2.

51; 95% CI: 1.82, 3.47) and the clinical pregnancy rate (RR = 1.93; 95% CI: 1.

63, 2.29) in patients with a history of repeated implantation failure undergoing IVF.No differences were found in pregnancy outcomes of general IVF patients.Conclusions Granulocyte colony-stimulating factor is likely to be a potential option for infertility women undergoing IVF with thin endometrium or recurrent implantation failure.

Trial registration Retrospectively registered (The PROSPERO registration number: CRD42022360161).